Showing posts with label as. Show all posts
Showing posts with label as. Show all posts

Folic Acid and Vitamin B12 Improve Memory and Cognition as we Age

Thursday, May 22, 2014


Researchers from the Australian National University have shown that essential B vitamins combat stress that results in a loss of memory and normal thought patterns that cause abnormal brain aging. Publishingin The American Journal of Clinical Nutrition, scientists found that long-term supplementation of daily folic acid and vitamin B-12 promotes improvement in cognitive functioning after a period of two years, particularly in immediate and delayed memory performance.

B vitamins are crucial for nerve transmission and are needed in higher amounts as your stress level increases. Health-minded adults will want to ensure that they obtain an optimal daily dose of these important vitamins from diet or supplemental sources.

Folic Acid and Vitamin B-12 Fight Brain Stress and Inflammation in the Elderly
The study leader, Dr. Janine Walker and her team conducted a two year intervention among elderly participants confined in a community-dwelling environment. All participants exhibited symptoms of depression and were under moderate stress due to environmental and lifestyle conditions. The study was designed to determine if nutritional intervention could prevent cognitive decline under randomized and controlled conditions.

Researchers supplemented one group of studyvolunteers with an oral dosage of 400 micrograms of folic acid and 100 micrograms of vitamin B-12 daily. This group was compared against a control set of participants that received a placebo. The results were measured at twelve and twenty-four month intervals using the Telephone Interview for Cognitive Status Standardized Test and the Brief Test of Adult Cognition by Telephone (to determine processing speed). An Informant Questionnaire on Cognitive Decline in the Elderly was administered at two years to provide a final analysis of cognitive function.

B Vitamin Duo Synergistically Improves Memory Performance in Aging Adults
The study authors found that the group receiving the supplemental B-vitaminsexperienced significantly better memory function when compared to the control subjects. The research team determined that stress results in inflammation to neuron structures in the brain and inhibits electrical and chemical transmissions between nerves that are required to form new memories and maintain a healthy degree of cognitive function. The body uses B-vitamins, especially folic acid and vitamin B-12 to fight brain inflammation and ensure proper brain communications.

After the two year study period, Dr. Walker concluded“Long-term supplementation of daily oral 400 mcg folic acid and 100 mcg vitamin B-12 promotes improvement in cognitive functioning after 24 months, particularly in immediate and delayed memory performance.” The entire family of B-vitamins has been shown to lower the impact of brain stress and inflammation. Health-conscious adults will want to combine a daily supply of B-vitamins with the Omega-3 fats EPA and DHA to dramatically lower the risk of memory loss and cognitive decline.
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Green Tea Helps Maintain Cognitive Ability as We Age

Monday, May 19, 2014


Green tea has long been hailed as a cardio-protective beverage due to its ability to lower levels of oxidized LDL cholesterol, an established heart disease risk factor. It has also been shown to promote brain health because the active compound, EGCG (Epigallocatechin gallate) freely crosses the blood-brain barrier to provide antioxidant support and lower damaging levels of brain inflammation.

Researchers from Japan reporting in the American Journal of Clinical Nutrition demonstrate that regular green tea consumption lowers the risk of developing functional disabilities that lead to problems with daily chores and activities, such as bathing or dressing. Drinking up to five cups of green tea each day can lower the risk of developing functional disabilities as we age by nearly one half.

Daily Green Tea Consumption Significantly Lowers Risk of Functional Decline
Prior studies have determined that consuming green tea lowers the risk of diseases associated with functional disability, such as osteoporosis, cognitive impairment and stroke. To date, no formal studies have been conducted to confirm the impact of green tea consumption on functional ability. Researchers from Tohoku University Graduate School of Medicine in Japan modeled this study to affirm the positive results associated in the past with drinking green tea.

To design this research work, scientists handed out questionnaires to nearly 14,000 respondents aged 65 or older. The participants answered questions about general diet, green tea consumption and lifestyle. After a period of five years, researchers were able to find a close inverse link between functional disability risk and the consumption of green tea. Higher intake of green tea was associated with a dramatically lower risk of functional disability in the group studied.

Green Tea Drinking Lowers Risk of Functional Disability in the Elderly
The research team concluded that nearly13% of the participants consuming the lowest amount of green tea (one cup or less each day) developed moderate to severe degrees of functional disability. By contrast, only 7% of those consuming the highest amount of green tea (5 cups or more each day) were classified with any degree of functional decline. The highest level of green tea consumption was shown to cut the risk of functional and cognitive decline by close to one-half.

The researchers noted that those consuming five or more cups of green tea each day also ate more fruit and vegetables, consumed more fish, were less likely to smoke, had fewer strokes or heart attacks, and tended to have a higher level of education. Improved dietary and lifestyle considerations are synergistic factors that compliment green tea consumption and likely contribute to the positive results in this study. Health-minded individuals already follow strict dietary principles to maintain brain health and functional abilities. Drinking 5 or more cups of green tea each day are shown to boost the healthy benefits associated with proper nutrition and lifestyle.
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The choir as healthy with yoga

Sunday, May 4, 2014

The choir as healthy with yoga - For some people, following the choir can be a hobby or their career path. However, research shows that sang in the choir can provide health benefits.

Researchers found that when singing in the choir, the singers do not simply equate the tone but also heart rate. Scientists assume that this is due to the coordination of breath from the singer.

Singing in a choir is also known to help the body to control breathing and regulate heartbeat. Melody and musical structure is also directly related to the activity of the heart of the singer.

"Songs with long phrases to help someone achieve the same effect with breathing exercises in yoga exercise," said Dr. Bjorn Vickhoff, lead researcher, as reported by the Metro.

It is found in research after they observed 15 choir singers when they sing a different tune. The song is slowly giving the highest alignment. In addition, Vickhoff also found that singing can help people cope with difficulties breathing.

Now researchers will conduct further studies to see how music can affect the biological body.
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Are Rising Health Care Costs As Bad As We Think They Are

Wednesday, April 23, 2014

When pundits claim that health care spending is out of control, what do they mean?

Does it mean that Massachusetts outlawing of hospitals excessive price increases is a good thing? That rolling back the Affordable Care Act will automatically usher in a new round of price gouging? That when the DMCB generates another medical co-pay, the DMCB spouse is right to wave a copy of the bill around and demand that the DMCB do something now to orm the U.S. health care system?

As the Disease Management Care Blog understands it, what the pundits, Massachusetts legislators, patient advocates and the DMCB spouse mean is that more and more of our nations gross domestic product (GDP) is being spent on health care services.

That assumes wed all be better off if the U.S. were spending its national treasure on stuff like manufacturing, technology, education and innovation. So, instead of committing just under 18% of our output on hospital care, physician services, nursing homes, medical devices and drugs, wed all be better off if we spent it on the production of solar panels, Facebook, public school vouchers and iPhone apps.

That way we wouldnt be struggling with the prospect of another 1% gain on GDP (to 19%) and the looming possibility that well soon be spending a whopping fifth of our economy on health care.

But is the spending on health care really that bad?  As noted here, the DMCB pointed out that non-government-insured health care costs have been moderating for years.  Whats more, recent year-to-year increases in health care spending in the U.S. are actually lower than much of the developed world.

And now theres one more reason to doubt the prevailing wisdom about rising health care costs. Charles Roehrig, Ani Turner, Paul Hughes-Cromwick and George Miller of the curiously name Altarum Institute point out that the normally rising and falling GDP associated with routine economic cycles can make steady health care costs look relatively worse or better than they appear.

To dampen the impact of a cyclic economy on the assessment of health care spending, the authors compared health spending to U.S. "potential GDP." Apparently, this obscure economic metric has been used by economists to portray what GDP would be if the economy were operating at full employment of the current population and without any idle production capacity.  This metric has the advantage of "smoothing out" many of the peaks and valleys of the normally measured GDP.

Using potential GDP as the comparative baseline, the authors found that health care spending growth gained less than 1% of the economy starting in July of 2005, well before the onset of the Great Recession of 2008. In other words, during that time, the health care industry grew pretty much at the same rate as the "potential" GDP. 

Whats more, in June of 2009, health care cost growth gained an additional 1% of potential GDP, only to fall back below 1% again in May of 2011.  Most of the increases seemed to be accounted for by Medicare Part D spending; if that particular cost is backed out, excess growth would have been 1% or less throughout the measurement period.

The authors can only hypothesize on why health care costs didnt outstrip the U.S. economy. While it could be partially accounted for by the rising numbers of uninsured (who would have avoided going to hospitals or seeing doctors), the authors point out that other trends could have played a role: changing physician practice standards, increasing numbers of salaried physicians, market pressures pushing down on fee schedules, increases in patients out-of-pocket expenses making them less likely to access the care system, new care models (including disease management?), the increasing use of generics, previously expensive drugs going off patent and the drop-off in the number of "blockbuster" pharmaceuticals.

This means when the economy bounces back and/or Obamacare results in more insured Americans, there is no guarantee that underlying health care inflation will return.
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Lower Body Weight as we Age Linked to Increased Alzheimer’s Disease Risk

Wednesday, April 16, 2014


Many lifestyle factors are associated with the development of the memory-robbing form of dementia known as Alzheimer’s disease. Smoking, diet, lack of exercise and poor B-vitamin status all contribute to the sixth most prevalent cause of death each year in the US. Past studies have shown that excess weight in mid-life increases the risk of developing Alzheimer’s disease.

Evidence published in the journal Neurology finds that low body weight (as measured by Body Mass Index or BMI) is a strong predictor for those at risk of developing this most devastating form of dementia. Proper weight management at all stages of life is critical to lower the risk for developing Alzheimer’s disease.

Underweight during Advancing Years Associated with Increased Alzheimer’s Disease Risk
Natural health followers have long known that excess abdominal fat and obesity are critical factors that promote an unhealthy cascade of metabolic reactions that lead to cognitive decline and eventually, Alzheimer’s disease. The result of a new study explains the delicate relationship between body weight and dementia risk, as advancing years and a lower BMI are show to significantly increase risk for future development and progression of the disease.

Researchers examined 506 people with advanced brain imaging techniques and analyses of cerebrospinal fluid (CSF) to look for biomarkers associated with Alzheimers disease. Many biochemical markers are known to be present years before the first symptoms begin. The group was comprised of people with no memory problems, people with mild cognitive impairment, or mild memory problems, and people with a diagnosis of Alzheimers disease.

Study Finds Direct Link between Low BMI and Amyloid Brain Plaque Formation
After testing body weight and reviewing the results of CSF and brain imaging tests, scientists found that in people with no memory or thinking problems and in people with mild cognitive impairment, those who had the Alzheimers biomarkers were also more likely to have a lower BMI than those who did not have the biomarkers. Dr. Jeffrey Burns, the study leader noted, “85 percent of the people with mild cognitive impairment who had a BMI below 25 had signs of the beta-amyloid plaques in their brains that are a hallmark of the disease, compared to 48 percent of those with mild cognitive impairment who were overweight.” 

Researchers conducting the study determined that low body weight and advanced age may result in damage to an area of the brain called the hypothalamus that plays a role in regulating energy metabolism and food intake. Dr. Burns concluded “These results suggest Alzheimers disease brain changes are associated with systemic metabolic changes in the very earliest phases of the disease.” The information provided by this study underscore the importance of maintain a healthy body weight (for most people measured with a BMI range of 20 to 25) throughout life and advancing years to lower the risk of developing Alzheimer’s disease.
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Is High Blood Pressure In The Elderly Not As Risky

Thursday, April 3, 2014

The risks associated with hypertension, high blood pressure (BP) as its commonly called, may be different for very old compared to younger adults. Paula Span, who writes the New Old Age Blog at the New York Times discussed this in her post:

For the Very Old, a Surprise in Blood Pressure Readings, New York Times, 8 August 2012

Span writes:
"I was startled to learn that in the very elderly - those over 85, say - high blood pressure may indicate better health while lower numbers could mean trouble ahead."
Span had been reading a study and an accompanying editorial published in the Archives of Internal Medicine last year:

Rethinking the Association of High Blood Pressure With Mortality in Elderly Adults, JAMA Internal Medicine, August 2012
Comment on “Rethinking the Association of High Blood Pressure With Mortality in Elderly Adults," Goodwin JS, JAMA Internal Medicine, August 2012

In his editorial, Goodwin offered some background:
"In 1988, Matilla et al reported that, among the very old, elevated systolic and diastolic blood pressure (BP) were associated with longer survival. The differences were not subtle. The 5-year survival of those with systolic BPs greater than 200 mm Hg were almost twice as high as those with levels of 120 to 140 mm Hg. Over the ensuing 25 years, a substantial number of population-based studies have reported the same findings: in those older than 85 years (or older than 80 years in some studies), high BP is an excellent prognostic sign.

Perhaps the most rigorous assessment came from the Framingham Study, which reported that the strong positive association of BP with cardiovascular mortality was reversed between the ages of 75 and 85. Importantly, no population-based study has found the opposite, that high BP is a marker for bad outcomes in octogenarians. Conversely, “normal” BP is bad. Perhaps the worst sign is falling BP."
Why does high BP appear to be a good sign in an older population? Goodwin explains that the old are a mixture of frail and more robust individuals.  High BP does not connote the same level of health in both groups.  Referring to Diehr et al. he said:
"[The very old] showed a steady decrease in BP in the 3 years before death. ... High BP is only a good sign in very old age because many of those with “normal” BP have it for bad reasons."
When is it advantageous to treat high blood pressure in an older person? Goodwin says:
"Many robust, very old individuals have hypertension. Antihypertensive treatment in those individuals is beneficial. Frail older individuals are less likely to have hypertension, and treating those who do may produce bad outcomes."
How do you measure robustness? One good test is walking speed.

In the study at the top of this post, those with hypertension who could walk a 20-foot corridor at an average pace of 1.8 mph or better had about the same risk of dying as younger adults. Those with high BP who walked slower did not have an increased risk. And those with high BP who couldnt complete the walk had a 60% lower risk of death:
"Higher systolic BP was associated with an increased risk of mortality only among elderly adults who had a medium to fast walking pace. In contrast, among slower-walking older adults, there was not an association between elevated systolic or diastolic BP and mortality. Strikingly, we found elevated systolic and diastolic BP was strongly and independently associated with a lower mortality risk in participants who did not complete the walk test."
The lead author of the study, Dr. Michelle Odden, said:
"The paradigm in medicine is, high blood pressure is bad, treating it is good. We’re saying, maybe we need to look more closely at the guidelines and tailor them more to older adults."
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ACOs Run Amok as CCOs in Oregon

Friday, March 28, 2014

In 2011, the Oregon legislature approved the creation of Medicaid "coordinated care organizations" (CCOs). Once the initiative was granted waiver status by CMS, the "Oregon Health Plan" was launched. Its regulated and funded by the "Oregon Health Authority," which also oversees the health insurance for Oregons public health employees. When it became clear that contracting for the states public employee business was tied to the CCO participation, most of the larger health systems in Oregon responded by signing up to be CCOs.

According to Eric Stecker writing in the Feb 13 the New England Journal of Medicine, "there is a distinct possibility it could fail."

Yikes.

The planning for CCOs was ultimately based on the assumption that its capitation-based payment methodology would achieve a 2% reduction in costs versus a 5.4% trend. That assumption, in turn, enabled Washington DCs waiver that included $1.9 billion in funding. Unfortunately, that money was tied to penalties if the savings are not achieved.

CCOs signed up with primary care medical homes, promises of clinical integration and a commitment to greater coordination of care. Yet, when Dr. Stecker reviews the Oregon health care landscape, he sees little proof that medical homes are achieving large savings, that the arms race of local competition has moderated or that the movement of patients across care settings is seamless and efficient. Whats more, local health providers within the CCOs are largely autonomous and fee-for-service remains the dominant payment methodology for these health systems other lucrative payers. The likelihood that theyre going to change their culture or their clinical work flows to serve the CCO segment of their business is remote.

Dr. Stecker correctly identifies the unproven assumptions that underlie the belief that physician-hospital organizations can cut out the middleman insurers and manage global risk contracts with the pixie dust of medical homes and care coordination.  While those ingredients are necessary, the Disease Management Care Blog agrees that the likelihood of CCOs ending the year with a 2% reduction in claims expense is a stretch. 

The DMCB will stay tuned.

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Respiratory infections as infants increase the risk of diabetes

Friday, March 21, 2014

Respiratory infections as infants increase the risk of diabetes - Although it seems trivial, but diseases such as mild respiratory infection that occurs when children aged zero to six months may increase a childs risk for developing type 1 diabetes until doubled. If the child is exposed to a respiratory infection at the age of six months to 12 months, the risk will be reduced to 32 percent.

Even so, the researchers stressed that this could be not the same for all children, because this study is only performed on children who have a high risk of diabetes, the child who has had a family history of diabetes.

"In general, the immune system is still in its infancy when the kids were babies. To that end, the immune system is still vulnerable if challenged by the virus that causes the infection," said study author Andreas Beyerlein, from the Institute of Diabetes Research in Munich, as reported by U.S. News.

These results were found after researchers followed 148 children aged under three months. All infants had family members and relatives who have type 1 diabetes. Researchers recorded history of infection and illness experienced by babies what ever suffered by the child until they are three years old.

At the end of the study, scientists found that children exposed to respiratory infection at the age of six months had a risk of developing type 1 diabetes are two times greater than children who did not experience respiratory infections. Beyerlein explained that not only affect the number of infections, but also time and age when exposed to infection.

Furthermore, Beyerlein suggested that parents who have a child at risk of developing type 1 diabetes keep their children from possible respiratory infection in infancy. It is necessary to avoid increasing the risk of children developing diabetes as adults. Researchers will conduct further studies to identify the type of virus that can cause infection and lead to increased risk of diabetes in infants.
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Titanic As Metaphor Ten Lessons for Medicare

Thursday, January 30, 2014

Even on the 100th anniversary of RMS Titanics sinking, the Disease Management Care Blog cant make it through a single sitting of either A Night to Remember or James Camerons Titanic.  It only cares to watch the films last half hour.

That doesnt mean that the DMCB cant use the tragedy as a Medicare metaphor. 

To wit:

1.  We still believe the guarantee that Medicare is unsinkably going to meet its obligations.

2.  The threat is a huge fiscal iceberg that we know exists. It will not be seen until it is too late.

3.  Medicares design experts were likewise stunningly wrong.

4  The regulations, made years if not decades ago, remain hopelessly obsolete.

5. The twin unpredictable Black Swan mirages and tides of a) "savings" and b) technology can only be recognized in retrospect.  And there are other "unknowns" out there.

6.  Those presently in charge can be wrong about remaining calm: if the ship is listing, its time to panic and run for the lifeboats.

7. Once disaster strikes, ill-conceived actions can make things worse.

8.  Whether its news or movie media, much of what we think we know is a littered with historical inaccuracies.

9.  If the ship goes down, the lowest socioeconomic classes will suffer the most.

10. When we deal honestly with the lessons of a disaster, we can eventually build a better and safer system.
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Violence as a small increase womens risk of thyroid disease

Monday, January 13, 2014

Violence as a small increase womens risk of thyroid disease - Violence perpetrated on children not only a bruised scar lost in a matter of weeks, but also other issues that will be there until they are adults.

A study revealed that women who experienced physical abuse as children have an increased risk of thyroid disease more than women who did not experience physical abuse as a child.

"We found a significant association with thyroid disease in women who have experienced violence in childhood," said lead researcher Esme Fuller Thomson, professor of the University of Toronto;s Faculty of Social Work, as reported by U.S. News .

Thomson explained that first they thought it must be related to stress, smoking, drinking alcohol, and other factors related to violence as a child. But in fact, after accounting for all factors, the researchers found that the risk is still quite large, namely 40 percent in women who have experienced violence as a child.

These results were found after researchers analyzed data from 13,000 adults in Canada. More than 1,000 women are known to experience physical violence before the age of 18 years and about 900 women said they had thyroid disease.

Loriena Yancura, assistant researcher from the University of Hawaii explained that the possibility of it is influenced by the trauma experienced by women due to physical abuse as a child. Trauma then change the way their bodies respond to stress to adults and are associated with thyroid.
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