Showing posts with label bone. Show all posts
Showing posts with label bone. Show all posts
Avandia Linked to Bone Loss in Mice
Tuesday, May 20, 2014
Research funded by the National Institutes of Health and the Howard Hughes Medical Institute, and appearing in this months online issue of Nature Medicine, has shed light on why women in one study who took Avandia (rosiglitazone) had decreased bone density. (See our post from earlier this year: Questions Surrounding Avandia and its Effect on Bone.)Bone is not the static organ many people think. Its constantly being ormed. Cells called osteoclasts break down bone while cells called osteoblasts lay down new bone.
These researchers found that mice given the PPAR-gamma agonist Avandia (Avandia is a thiazolidinedione, a class of insulin-sensitizing drugs under which Actos also falls) had increased activity of their osteoclasts, leading researchers to speculate:
"These findings have potential clinical implications, as they suggest that long-term rosiglitazone usage in the treatment of type 2 diabetes and insulin resistance may cause osteoporosis, owing to a combination of decreased bone formation and increased bone resorption."If more studies support this link, it may necessitate screening patients for osteoporosis before starting or continuing them on these drugs.
Nature Medicine abstract:
PPAR-gamma Regulates osteoclastogenesis in Mice
News summaries:
Diabetes Drug Link To Weak Bones
Diabetes Drug May Increase Bone Thinning
Six Ways To Stop Bone Loss During The Menopause Transition
Tuesday, April 1, 2014
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| Bones |
Six Ways To Stop Bone Loss During The Menopause Transition - You’ve probably heard that women are prone to losing bone during menopause. For the most part, nature has provided healthy women with ample bone mass to accommodate this perimenopausal and menopausal bone loss, but some women can end up with dramatically less bone mass than when they began the transition — up to 20% for a few women I see at the Center for Better Bones.
Our bones naturally break down and rebuild themselves on a daily basis, and until women reach the age of 30, the building of bone outweighs breakdown. Shortly after peak bone mass is reached — somewhere around our 29th birthday — we begin to lose bone density. This loss seems to accelerate in many women during the menopause transition. And for many years, the medical and research community blamed estrogen. But as it turns out, estrogen is not the only factor responsible for bone health during the menopause transition. Neither is calcium for that matter. The truth is, finding one definitive cause for thinning bone during menopause is unrealistic. Bone mineral density loss during menopause depends on a combination of factors.
The good news is that in most cases, accelerated bone loss slows down within five to seven years after your last period. So the window of time we are most concerned about is the few years before and the few years after your last period. There is also a lot you can do to preserve your bone density — or even increase it — during this time.
Let’s take a look at how you can keep your bones strong and healthy through menopause so you can give yourself the best possible foundation for the second half of your life!
1: Make nutrition your first priority
There are at least 20 key nutrients that are required for optimal bone health. A balanced diet containing a range of vegetables and fruit, whole grains, seeds and nuts, and lean protein will help supply these nutrients, while supporting the body’s acid-alkaline balance.
Many of us in the US are suffering from chronic low-grade metabolic acidosis because of our diets. Foods like excess animal protein, ined grains, excess sugar, sodas, and preservatives can cause the pH in our blood and tissues to become slightly more acidic than is optimal. And when this happens the bones release their alkalizing mineral compounds into the blood to “rescue” our all-critical pH balance. This happens at the expense of bone mineral density and maintaining the living bone protein matrix. Eating more alkalizing fruits and vegetables and less acidifying animal proteins, grains, and processed foods can prevent your body from drawing on mineral reserves stored in your bones to offset a highly acidifying diet.
Since no diet is perfect, I also recommend women take a high-quality supplement specifically formulated for bone health to fill any nutritional gaps. It’s important to understand that micronutrients interact with each other and that simply taking one, such as calcium, is never as helpful as getting a well-rounded nutrient base. That being said, menopausal women should pay special attention to increasing vitamin D and vitamin K intake. Here are some of the reasons why:
Tips on getting vitamin D from the sun
- Limit sun exposure to before 10:00 a.m. and after 2:00 p.m. during summer months to prevent skin damage.
- Expose the skin to full sun for 30 minutes per day — longer if you’re dark-skinned. But don’t allow yourself to burn.
- If you’re light-skinned and concerned about sunburn, sun exposure in increments — three 10-minute exposures at different times in the day, rather than one 30-minute stretch.
- If you live above 40° latitude (a horizontal line running below New York City west to northern California), the sun is only strong enough to trigger vitamin D synthesis between May and September. From October through April, you will need to supplement your diet with other vitamin D sources.
Vitamin D. Adequate vitamin D levels are critical for us to absorb calcium in our intestines and to metabolize calcium throughout life. Without enough vitamin D, less than 10% of ingested calcium may be absorbed. The role vitamin D plays in menopause is very clear. As estrogen levels drop, the bone breakdown hormone known as parathyroid hormone tends to increase. Vitamin D has been shown to limit the rise in parathyroid hormone and, in turn, limit bone breakdown.
Unfortunately the majority of Americans are deficient in vitamin D. Aside from compromising bone, low vitamin D levels are linked to life-threatening diseases like cancer, diabetes, and heart disease, as well as other conditions like depression and circulatory disorders. Simply exposing the skin to full sun triggers vitamin D production in the skin.
But there is no guarantee you will achieve adequate vitamin D levels without appropriate supplementation. In my office I have seen remarkable variation in my patients’ levels of vitamin D, so I always suggest that everyone has her vitamin D level tested. Optimal levels are between 50–60 ng/mL. Testing is the only way to really know if you have enough of this life-saving nutrient. Recent research suggests an ideal intake of 2000 IU vitamin D3 daily for the average person.
Vitamin K. Along with D, vitamin K has very recently been recognized as essential to bone health, and many, if not most, menopausal women in America are deficient in it. Vitamin K is a key player in the formation of the bone protein osteocalcin and the binding of calcium to the bone matrix. It also limits how much calcium we excrete in our urine. Vitamin K has been associated with higher bone mineral density, reduced bone breakdown, and lower risk of fracture. During the early stages of menopause, vitamin K metabolism is altered in many women, and intake may need to be increased during this transition.
Ovary removal may be associated with an even greater reduction in vitamin K status than natural menopause. A 2006 study found that after ovary removal, the concentration of undercarboxylated osteocalcin (an inactive form of osteocalcin) increased quickly, suggesting that there wasn’t enough vitamin K on board to carboxylate and activate the protein. Thus scientists now suggest that the need for vitamin K is higher in both natural and surgical menopause.
- Foods rich in vitamin K
- Sauerkraut
- Aged cheese
- Natto
- Kimchee
I encourage you to increase your intake of both vitamins K1 and K2 (also known as MK-7) during the menopausal transition because I’ve seen what a difference it makes. For added vitamin K in food, see the list at left. If you are wisely thinking of supplementing with vitamin K, your bones will benefit most from the form of vitamin K2 known as MK-7 (menaquinone), so look for this to be included in your bone health supplement. At the Center for Better Bones, we are conducting a clinical trial using MK-7 to halt menopausal bone loss. Our preliminary results look promising, and I’ll keep you informed about our vitamin K / MK-7 research as we complete this exciting study.
2. Preserve and build muscle mass
Like our bone mass, our muscle mass generally reaches its peak in youth, then progressively decreases as we age. By the time women are transitioning through menopause, they have been steadily losing muscle since around the age of 30 — unless they’ve made an ongoing effort to maintain muscle strength. This makes it more important than ever to exercise during the years leading up to and right after menopause.
Save muscle with an alkaline diet
According to a 2008 study, scientists have now documented that an alkaline diet helps to preserve muscle mass as we age.
We’ve known for a long time that exercise helps to build bone. After all, our bones adapt to the stress we put on them, so the more we use them the stronger they become. This is somewhat more difficult for women in perimenopause and menopause because of the other stressors their bodies are dealing with and the tendency to lose bone rather than build it. But intensive strength training allows many women to regain bone as they build muscle. Exercise studies show that women in early post-menopause can not only maintain, but gain an average of 1.5% in bone mineral density in as little as nine months with rigorous strength-training regimes — a far cry from the 2% of lost bone that might otherwise occur.
Even simply doing aerobic exercise three times per week for half an hour, or a regular practice as gentle yet powerful as Pilates, can do wonders for preventing bone loss. If you’re interested in learning more about strength training for your bones, you can take a look at Miriam Nelson’s book, Strong Women, Strong Bones, or Wayne Westcott’s Strength Training Past Fifty.
3. Balance your hormones
Researchers always assumed the main reason for bone loss after menopause was a lack of estrogen — and estrogen does play a large role in bone health. For starters it can preserve calcium in the body by increasing our ability to absorb it in the intestine. It also prevents bone breakdown (resorption) by limiting parathyroid hormone, the hormone primarily responsible for releasing calcium from bone into the bloodstream, and by stimulating osteoprotegerin (OPG), a potent inhibitor of bone resorption. These are some of the reasons why millions of women were put on hormone replacement therapy after menopause.
But when scientists took the trouble to study the stage immediately before menopause — known as perimenopause — they found that a great deal of bone loss occurs in women before their last period. This complicates things, because women are known to have a rollercoaster ride of spikes and dips in estrogen levels combined with low progesterone levels during perimenopause. So the cause and effect relationship between estrogen and bone loss becomes less definitive.
Over the years, noted Canadian endocrinologist Dr. Jerilynn Prior and others have conducted research on the effects of progesterone on bone. Progesterone, in many cases, is the hormone to decrease first in the perimenopause transition. Dr. Prior’s work shows that progesterone and our bone-building cells, called osteoblasts, have a complex relationship and progesterone may help build bone, although others have had different results. There is also recent evidence showing that a natural increase in follicular stimulating hormone (FSH) during perimenopause may be linked to perimenopausal bone loss.
It’s clear that our sex hormones have an impact on the way our bones remodel themselves. During menopause these hormone levels are likely to change, with a consequent effect on bone building. But this does not mean you should turn to hormone replacement therapy, especially given the health risks of HRT. Mother Nature didn’t plan for our bodies to maintain reproductive levels of estrogen and progesterone throughout life, and your bones don’t require them to stay healthy. All things in life are cyclical, including our hormones, and the body can adapt. We just have to take care to support it in the transition.
You can do this in many ways, one of which is by eating a well balanced diet full of fresh whole fruits and vegetables, high-quality protein and fats. Herbal therapies (phytotherapy) can also gently help your body restore its hormonal balance.
4. Take care with weight loss
Many women are surprised to hear that losing weight can be a significant risk factor for bone loss in perimenopausal and recently menopausal women. It’s not that weight loss is itself necessarily unhealthy — if you’re overweight or obese, it’s still a good idea to address the health issues that have led to your excess weight. But the methods you use to lose weight are very important, and I would caution all women who plan to lose weight during the years leading up to and right after the menopausal transition to take rigorous steps to protect their bones.
Researchers all around the world have noticed that the combination of low weight and advancing age are the most important risk factors for determining low bone density. In fact, if a practitioner does no other tests or screening at all, she can predict who is likely to have low bone density simply by looking at age and weight. And when postmenopausal women lose weight, they tend to lose bone. The numbers indicate that a 10% loss in body weight will give you about 1% loss in bone mass.
We’re not entirely sure why women lose bone when they lose weight. More research is needed in this area, but here are some possibilities. First, simple physics tells us that women who are thin have less weight to carry around, and theore the everyday force of impact placed on their bones is lower than what an average or overweight woman sustains — so their bones receive fewer signals to regenerate in the course of daily life. Second, weight loss causes the release of bone-detrimental toxins that have accumulated in fat cells over the years. Third, fat cells are secondary producers of estrogen, which helps protect against bone loss.
Personally, my favorite theory is that our prevalent chronic low-grade metabolic acidosis is worsened by calorie restriction, high animal protein and/or high fat diets leading to a loss in the urine of calcium and other bone nutrients. Ultimately, how you lose weight is a key factor in whether your weight loss improves your health (see our articles on healthy weight for more information).
Data from a large, six-year study done in Scotland showed that Caucasian women (already at higher risk for low bone density than other ethnicities) who lost weight in the stage leading up to menopause and shortly thereafter lost greater bone density than participants who did not lose weight during this time. Although it was the change in weight rather than low weight per se that was associated with loss of hip bone mineral density, lower weight at follow-up was associated with greater loss of spinal bone, suggesting that both low weight and losing weight result in lower bone density overall.
What all this means in sum is that women approaching menopause who want or need to lose weight should do so in a thoughtful, planned way that is targeted toward improving their whole health so they don’t lose bone along with the weight. Nutritional support during your weight loss is key: a healthy diet and appropriate nutritional supplements are important. If you plan to lose weight during the menopause transition, be sure to do the following to protect your bones:
Engage in healthy exercise that builds muscle. Some examples include weight-training, yoga, qi gong, t’ai chi, and Pilates.
Decrease your body’s acidity by following an alkaline diet.
Supplement with the 20 key bone-building nutrients.
Get your vitamin D levels tested and supplement with vitamin D and K as needed.
5. Decrease inflammation and improve digestion
Chronic inflammation has very recently been discovered as another factor in bone loss. Our bodies become “inflamed” when they are reacting to a situation that calls for the activation of the immune system, such as an injury or disease. Persistent exposure to food allergies or a generalized deficiency in healthy gut bacteria can also lead to chronic inflammation in the body. And when inflammation starts in (or is centered around) the gut, it can affect our ability to absorb bone-building nutrients.
Inflammatory disorders that impact your bones
- Diabetes
- Heart disease
- High blood pressure
- High cholesterol
- Irritable bowel syndrome
Interestingly, our bone breakdown osteoclast cells share a common precursor with immune cells. Consequently, when the immune system is recurrently activated, the body overproduces bone breakdown cells, and bone is broken down more readily than it would be otherwise.
Inflammation’s harmful effects on bone tend to accelerate during menopause for two reasons. First, estrogen has a natural anti-inflammatory effect, and during menopause estrogen levels decline. Second, as we age inflammatory free radicals and oxidative stress accumulate, which increases bone breakdown and lowers bone mineral density.
There are useful ways to lower your inflammation that can definitely serve your bones. Solving gastrointestinal problems is a good place to start, since soothing an irritated GI tract could help reverse inflammation throughout the body. Pay close attention to how you feel after each of your meals and see if any particular foods evoke a negative response. Sugar, caffeine, and ined carbohydrates tend to increase inflammation (and blood acidity), and foods like wheat, dairy, soy, nuts, and eggs also are common irritants. Daily omega-3 fatty acids have been shown to decrease inflammation, as has an alkaline diet. Turmeric and ginger have also historically been used to calm the immune system. (See our article on inflammation and bone loss to learn more.)
6. Reduce physical and emotional stress
There is an old saying that osteoporosis is common in thin, worried women. I’ve seen how worry and stress can compound bone loss in many women. Our bodies are under enormous physical stress during any hormonal transition — whether it’s puberty, pregnancy, or menopause. And the emotional stress that comes along with these transitions can add to the burden. Stress causes us to release higher levels of the fight-or-flight hormone cortisol, which in turn may lead to increased programmed cell death, or apoptosis, in our bone-building osteoblast cells.
Cortisol can weaken the bones and cause all kinds of other problems in our bodies when sustained at high levels over the years. Because our bodies are particularly stressed during the menopausal transition, it’s really important to incorporate stress reduction into our lives. At the clinic, we commonly find a connection between poor bone health and level of emotional support — when a patient has osteoporosis or osteopenia, it’s often the case that her low bone density mirrors a similar lack of solid support in her home life. So techniques to improve your emotional well-being are crucial in countering bone loss. My patients find meditation, yoga, t’ai chi, qi gong and other mind-body practices helpful in countering stress. T’ai chi, yoga, and qi gong are especially helpful because they facilitate stress reduction, build bone, strengthen muscles, and improve balance to prevent falls.
Stress can also stem from unresolved emotional issues that require more than the common forms of stress relief. You might also explore the possibility that stress may stem from a poor diet, food allergies, or prescription medication. The point is, stress reduction is an important factor that women often forego in the midst of their busy lives, and for the sake of their bones (as well as overall health) it shouldn’t be ignored.
An entry way for the healthy years to come
Menopause is a time for many women to rethink their roles and their lives in general. If bone health is a concern for you during this time you can transform this concern into a “window of opportunity” to improve your bones and improve your health overall. Poor bone health is a marker of systemic problems that affect the whole body, so the natural, life-supporting changes you make to strengthen your bones will help provide a sound foundation for a long and active life.
You don’t have to lose excessive bone during the menopausal transition or suffer from dangerous fractures in old age. Once you understand how to support your bones during this period of life, you have the power to work with nature to build and maintain strong bones. Hormone replacement and prescription drugs like Fosamax and Actonel are always a last resort in the Personal Program for Better Bones, because our bodies have the innate wisdom and the power to maintain lifelong healthy bones when we give them the right support.
6 Medical Conditions Linked to Osteoporosis and Bone Loss
Sunday, March 9, 2014
You probably know some of the leading risk factors for osteoporosis -- being female and past menopause, smoking, or having a small frame. But did you know that some fairly common medical conditions are also among the causes of osteoporosis bone loss?
If you have one of these conditions, either because of the disease itself or because of the medications you have to take to manage it, you face an increased risk of developing osteoporosis:
1. Diabetes Mellitus and Osteoporosis
For reasons scientists still dont fully understand, people with type 1 diabetes tend to have lower bone density.
Studies show that people with type 1 diabetes may have low bone turnover and lower than normal bone formation.
"It seems that high blood sugar may shut down bone formation, just as with steroids," says Beatrice Edwards, MD, MPH, associate professor of medicine and director of the Bone Health and Osteoporosis Center at Northwestern University Feinberg School of Medicine. Since type 1 diabetes usually develops in childhood, when the body is still building bone, someone with type 1 diabetes may never have the opportunity to reach their peak bone density.
Even if their bone mass isnt that much lower than normal, people with both type 1 and type 2 diabetes have a much higher risk of fractures than other people, adds Edwards.
2. Lupus and Rheumatoid Arthritis
Nearly 3 million adults in the U.S. have either lupus or rheumatoid arthritis. Both of these diseases are autoimmune conditions, in which the body attacks its own healthy cells and tissues, causing inflammation.
Any chronic inflammatory disease can put you at greater risk of osteoporosis, says Edwards, because it appears to increase the rate of bone turnover, in which old bone is replaced with healthy new bone. People with both lupus and RA usually take corticosteroids for an extended period of time to manage their symptoms. Long-term use of steroids such as prednisone is also a leading cause of osteoporosis, possibly because they slow the activity of bone-building cells.
Lupus is a particular problem because it is common in women between the ages of 15 and 45 -- often during the peak bone-building years up to age 30. "Anything that impedes the growth of bone during these years puts you at greater risk for osteoporosis," says Edwards.
3. Hyperthyroidism
Hyperthyroidism occurs when the thyroid gland -- a small, butterfly-shaped gland at the base of the neck -- becomes overactive and produces too much thyroid hormone.
"Hyperthyroidism increases the number of bone-remodeling cycles you go through," explains Edwards. "And after age 30, every bone-remodeling cycle is inefficient. You lose bone mass rather than building it. So the more cycles you go through, the more bone mass you lose."
Hyperparathyroidism, a similar condition involving related, but different glands, also ups the risk of osteoporosis.
4. Celiac Disease
A number of digestive disorders, such as Crohns disease, can be causes of osteoporosis. Perhaps the most common such cause, says Edwards, is celiac disease, an allergy to a protein called gluten that is often found in wheat products.
Left untreated, celiac disease can damage the lining of the digestive system and interfere with the digestion of nutrients -- including the calcium and vitamin D that are so important to bone health. So even if youre getting the recommended daily amounts of calcium and vitamin D in your diet, if you have celiac disease, you probably dont have enough of those nutrients in your system, and you likely have low bone density.
5. Asthma
Asthma itself does not increase your risk of developing osteoporosis, but the medications used to treat it do. Approximately 20 million people in the U.S. have asthma, including some 9 million children under the age of 18.
Many people with asthma use corticosteroids -- such as asthma "inhalers" -- to help control their disease. During asthma attacks it is not uncommon to start drugs like prednisone for small periods of time. These are very effective in relieving the shortness of breath and wheezing that are common with asthma or emphysema, but they may also contribute to bone loss and osteoporosis.
"In addition to this, many young people with asthma may have more difficulty participating in some activities, which means they might not get as much weight-bearing exercise as they need to help build bone," says Andrew Bunta, MD, associate professor and vice chair of orthopaedics at Northwestern University Feinberg School of Medicine.
6. Multiple Sclerosis
Asthma and multiple sclerosis are two very different conditions, but there are very similar reasons why they both increase the risk of osteoporosis. Like people with asthma, people with multiple sclerosis take steroid-based medications to help manage their symptoms, and steroids are associated with bone loss. Since multiple sclerosis also affects balance and movement for many people, someone with MS may find it more difficult to get as much weight-bearing exercise as they need to in order to build and maintain bone.
"Anything that impedes your ability to walk accelerates bone loss," says Edwards.
If you have one of these conditions, how can you help protect yourself from osteoporosis? First, dont assume that your doctor will take care of it for you.
"When you are troubleshooting a primary condition like MS, asthma, or lupus, youre not thinking about the side effects. Osteoporosis can take a back seat," says Felicia Cosman, MD, medical director of the Clinical Research Center at Helen Hayes Hospital in Haverstraw, N.Y., and an editor of Osteoporosis: An Evidence-Based Guide to Prevention and Management. "Thats understandable -- but you dont want osteoporosis to add more disability to an already disabling condition."
So if the doctor treating your celiac disease or rheumatoid arthritis hasnt already brought up osteoporosis with you, ask to discuss it. Depending on your age and your specific condition, you may have several options to help prevent osteoporosis symptoms:
* Get an early bone density test. Doctors dont usually recommend bone density tests for postmenopausal women, but if you have one of these conditions, you may need to be monitored more closely, and treated for bone loss more aggressively.
* Push for more vitamin D and calcium in your diet, and supplement. Edwards recommends that people with conditions that accelerate bone loss get at least 1,000 to 1,500 milligrams of calcium and 400 to 600 international units (IU) of vitamin D from food and supplements. Look for low-fat dairy and fortified foods.
* Consider getting the vitamin D levels in your blood measured. "Thats not a specific recommendation from the National Osteoporosis Foundation, but it makes so much clinical sense," says Cos man. "Because vitamin D levels vary so much between individuals, its hard to know how much supplementation is needed to reach sufficient levels."
If you have one of these conditions, either because of the disease itself or because of the medications you have to take to manage it, you face an increased risk of developing osteoporosis:
1. Diabetes Mellitus and Osteoporosis
For reasons scientists still dont fully understand, people with type 1 diabetes tend to have lower bone density.
Studies show that people with type 1 diabetes may have low bone turnover and lower than normal bone formation.
"It seems that high blood sugar may shut down bone formation, just as with steroids," says Beatrice Edwards, MD, MPH, associate professor of medicine and director of the Bone Health and Osteoporosis Center at Northwestern University Feinberg School of Medicine. Since type 1 diabetes usually develops in childhood, when the body is still building bone, someone with type 1 diabetes may never have the opportunity to reach their peak bone density.
Even if their bone mass isnt that much lower than normal, people with both type 1 and type 2 diabetes have a much higher risk of fractures than other people, adds Edwards.
2. Lupus and Rheumatoid Arthritis
Nearly 3 million adults in the U.S. have either lupus or rheumatoid arthritis. Both of these diseases are autoimmune conditions, in which the body attacks its own healthy cells and tissues, causing inflammation.
Any chronic inflammatory disease can put you at greater risk of osteoporosis, says Edwards, because it appears to increase the rate of bone turnover, in which old bone is replaced with healthy new bone. People with both lupus and RA usually take corticosteroids for an extended period of time to manage their symptoms. Long-term use of steroids such as prednisone is also a leading cause of osteoporosis, possibly because they slow the activity of bone-building cells.
Lupus is a particular problem because it is common in women between the ages of 15 and 45 -- often during the peak bone-building years up to age 30. "Anything that impedes the growth of bone during these years puts you at greater risk for osteoporosis," says Edwards.
3. Hyperthyroidism
Hyperthyroidism occurs when the thyroid gland -- a small, butterfly-shaped gland at the base of the neck -- becomes overactive and produces too much thyroid hormone.
"Hyperthyroidism increases the number of bone-remodeling cycles you go through," explains Edwards. "And after age 30, every bone-remodeling cycle is inefficient. You lose bone mass rather than building it. So the more cycles you go through, the more bone mass you lose."
Hyperparathyroidism, a similar condition involving related, but different glands, also ups the risk of osteoporosis.
4. Celiac Disease
A number of digestive disorders, such as Crohns disease, can be causes of osteoporosis. Perhaps the most common such cause, says Edwards, is celiac disease, an allergy to a protein called gluten that is often found in wheat products.
Left untreated, celiac disease can damage the lining of the digestive system and interfere with the digestion of nutrients -- including the calcium and vitamin D that are so important to bone health. So even if youre getting the recommended daily amounts of calcium and vitamin D in your diet, if you have celiac disease, you probably dont have enough of those nutrients in your system, and you likely have low bone density.
5. Asthma
Asthma itself does not increase your risk of developing osteoporosis, but the medications used to treat it do. Approximately 20 million people in the U.S. have asthma, including some 9 million children under the age of 18.
Many people with asthma use corticosteroids -- such as asthma "inhalers" -- to help control their disease. During asthma attacks it is not uncommon to start drugs like prednisone for small periods of time. These are very effective in relieving the shortness of breath and wheezing that are common with asthma or emphysema, but they may also contribute to bone loss and osteoporosis.
"In addition to this, many young people with asthma may have more difficulty participating in some activities, which means they might not get as much weight-bearing exercise as they need to help build bone," says Andrew Bunta, MD, associate professor and vice chair of orthopaedics at Northwestern University Feinberg School of Medicine.
6. Multiple Sclerosis
Asthma and multiple sclerosis are two very different conditions, but there are very similar reasons why they both increase the risk of osteoporosis. Like people with asthma, people with multiple sclerosis take steroid-based medications to help manage their symptoms, and steroids are associated with bone loss. Since multiple sclerosis also affects balance and movement for many people, someone with MS may find it more difficult to get as much weight-bearing exercise as they need to in order to build and maintain bone.
"Anything that impedes your ability to walk accelerates bone loss," says Edwards.
If you have one of these conditions, how can you help protect yourself from osteoporosis? First, dont assume that your doctor will take care of it for you.
"When you are troubleshooting a primary condition like MS, asthma, or lupus, youre not thinking about the side effects. Osteoporosis can take a back seat," says Felicia Cosman, MD, medical director of the Clinical Research Center at Helen Hayes Hospital in Haverstraw, N.Y., and an editor of Osteoporosis: An Evidence-Based Guide to Prevention and Management. "Thats understandable -- but you dont want osteoporosis to add more disability to an already disabling condition."
So if the doctor treating your celiac disease or rheumatoid arthritis hasnt already brought up osteoporosis with you, ask to discuss it. Depending on your age and your specific condition, you may have several options to help prevent osteoporosis symptoms:
* Get an early bone density test. Doctors dont usually recommend bone density tests for postmenopausal women, but if you have one of these conditions, you may need to be monitored more closely, and treated for bone loss more aggressively.
* Push for more vitamin D and calcium in your diet, and supplement. Edwards recommends that people with conditions that accelerate bone loss get at least 1,000 to 1,500 milligrams of calcium and 400 to 600 international units (IU) of vitamin D from food and supplements. Look for low-fat dairy and fortified foods.
* Consider getting the vitamin D levels in your blood measured. "Thats not a specific recommendation from the National Osteoporosis Foundation, but it makes so much clinical sense," says Cos man. "Because vitamin D levels vary so much between individuals, its hard to know how much supplementation is needed to reach sufficient levels."
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