Health for life

Had a bad day? Extending your normal exercise routine by a few minutes may be the solution, according to Penn State researchers, who found that peoples satisfaction with life was higher on days when they exercised more than usual.

"We found that peoples satisfaction with life was directly impacted by their daily physical activity," said Jaclyn Maher, graduate student in kinesiology. "The findings reinforce the idea that physical activity is a health behavior with important consequences for daily well-being and should be considered when developing national policies to enhance satisfaction with life."

The team examined the influence of physical activity on satisfaction with life among emerging adults ages 18 to 25 years because this populations sense of well-being appears to worsen more quickly than at any other time during adulthood.

"Emerging adults are going through a lot of changes; they are leaving home for the first time and attending college or starting jobs," said Maher. "As a result, their satisfaction with life can plummet. We decided to focus on emerging adults because they stand to benefit the most from strategies to enhance satisfaction with life."

The researchers recruited two groups of college students at Penn State. The first group, consisting of 190 individuals, entered information into a diary every day for eight days. The second group, consisting of 63 individuals, entered information into a secure website every day for 14 days. Both groups answered questions aimed at determining participants satisfaction with life, physical activity and self-esteem. The personalities of all participants in the first group were assessed at the outset of the study using the Big Five Inventory short form.

For the second group (the 63 individuals who filled out questionnaires online for 14 days), the researchers wanted to further investigate whether physical activity was indeed, the cause of participants increased satisfaction with life rather than some other factor such as mental health, fatigue, or Body Mass Index.

"Shifts in depression, anxiety and stress would be expected to influence a persons satisfaction with life at any given point in time," said David Conroy, professor of kinesiology. "In addition, fatigue can be a barrier to engaging in physical activity, and a high Body Mass Index associated with being overweight may cause a person to be less satisfied in a variety of ways."

By controlling for these variables, the researchers were able to determine that the amount of physical activity a person undertakes in a particular day directly influences his or her satisfaction with life. Specifically, the team found that by exercising just a little more than usual a person can significantly improve his or her satisfaction with life.

The results appeared online this week in the journal Health Psychology.

"Based on these findings, we recommend that people exercise a little longer or a little harder than usual as a way to boost satisfaction with life," said Conroy.

Research has shown that exercise is good for the brain. Now investigators have identified a molecule called irisin that is produced in the brain during endurance exercise and has neuroprotective effects. Researchers were able to artificially increase the levels of irisin in the blood to activate genes involved in learning and memory. The findings, published online October 10 in the Cell Press journal Cell Metabolism, may be useful for designing drugs that utilize this exercise-induced molecule to guard against neurodegenerative diseases and improve cognition in the aging population.

While its known that exercise can boost cognitive function and lessen symptoms of neurological diseases like depression, stroke, and Alzheimers disease, the mechanisms underlying these effects are unclear. One important player is thought to be a growth factor named brain-derived neurotrophic factor (BDNF).

Through experiments conducted in mice, investigators led by Dr. Bruce Spiegelman of the Dana-Farber Cancer Institute and Harvard Medical School found that a molecule called FNDC5 and its cleavage product, irisin, are elevated by endurance exercise in the brain and increase BDNF expression. On the other hand, mice genetically altered to have low irisin levels in the brain had reduced levels of BDNF.

The team also found that raising levels of irisin in the circulation caused the molecule to cross the blood brain barrier, where it increased expression of BDNF and activated genes involved in cognition.

"Our results indicate that FNDC5/irisin has the ability control a very important neuroprotective pathway in the brain," says Dr. Spiegelman. The researchers next plan to work on developing a stable form of the irisin protein that can be given to mice by injection and may augment the brains natural anti-degeneration pathways.

Helps stave off major ill health and dementia even for those getting started relatively late

Its never too late to get physically active, with even those starting relatively late in life reaping significant health benefits, finds research published online in the British Journal of Sports Medicine.

Four years of sustained regular physical activity boosted the likelihood of healthy ageing sevenfold compared with consistent inactivity, the findings show.

The researchers tracked the health of almost 3500 people, whose average age was 64, for more than eight years. All were participants in the English Longitudinal Study of Ageing, which involves a nationally representative sample of the household population of England, born on or before 29 February 1952.

The researchers wanted to quantify the impact of physical activity on the risk of developing long term conditions, depression, and dementia, and on the likelihood of "healthy ageing."

This is usually taken to mean not only an absence of major disease and disability, but also good mental health, the preservation of cognitive abilities, and the ability to maintain social connections/activities.

Theres a growing body of evidence to suggest that regular physical activity is essential for the maintenance of good health, while across the developed world, inactivity is ranked alongside smoking, excess drinking, and obesity as a leading cause of reduced life expectancy.

Participants described the frequency and intensity of regular physical activity they did in 2002-3, and then every subsequent two years until 2010-11.

Their responses were categorised as: inactive (no moderate or vigorous activity on a weekly basis); moderately active (at least once a week); and vigorously active (at least once a week).

Any changes in frequency and intensity were noted at the two yearly monitoring sessions: always inactive; became inactive; became active; always active.

Serious ill health, such as heart disease/stroke, diabetes, emphysema, or Alzheimers disease, was confirmed by medical records.

Cognitive abilities and mental health were assessed using a battery of validated tests, while disability was measured according to participants responses to questions about the ease with which they were able to carry out routine activities of daily living, and an objective test of walking speed.

Nearly one in 10 of the sample became active and 70% remained active. The rest remained inactive or became inactive.

At the end of the monitoring period almost four out of 10 had developed a long term condition; almost one in five was depressed; a third had some level of disability; and one in five was cognitively impaired.

But one in five was defined as a healthy ager. And there was a direct link to the likelihood of healthy ageing and the amount of exercise taken.

Those who had regularly indulged in moderate or vigorous physical activity at least once a week were three to four times more likely to be healthy agers than those who had remained inactive, after taking account of other influential factors.

Those who became physically active also reaped benefits, compared with those who did nothing. They were more than three times as likely to be healthy agers.

And those who sustained regular physical activity over the entire period were seven times as likely to be healthy agers as those who had consistently remained inactive.

"This study supports public health initiatives designed to engage older adults in physical activity, even those who are of advanced age," conclude the authors.

Women who watch their weight and closely follow a Mediterranean-style diet high in vegetables, vegetable oils, fish and beans may increase their chance of becoming pregnant, according to dietitians at Loyola University Health System (LUHS).

"Establishing a healthy eating pattern and weight is a good first step for women who are looking to conceive," said Brooke Schantz, MS, RD, CSSD, LDN, LUHS. "Not only will a healthy diet and lifestyle potentially help with fertility, but it also may influence fetal well-being and reduce the risk of complications during pregnancy."

Thirty percent of infertility is due to either being overweight or underweight, according to the National Infertility Association. Both of these extremes in weight cause shifts in hormones, which can affect ovulation. Reducing weight by even 5 percent can enhance fertility.

Schantz recommends the following additional nutrition tips for women who are looking to conceive:

-Reduce intake of foods with trans and saturated fats while increasing intake of monounsaturated fats, such as avocados and olive oil

-Lower intake of animal protein and add more vegetable protein to your diet

-Add more fiber to your diet by consuming whole grains, vegetables and fruit

-Incorporate more vegetarian sources of iron such as legumes, tofu, nuts, seeds and whole grains

-Consume high-fat dairy instead of low-fat dairy

-Take a regular womens multivitamin

Approximately 40 percent of infertility issues are attributed to men, according to the American Society for Reproductive Medicine. Among them is low sperm count and poor sperm motility, which are common in overweight and obese men.

"Men who are looking to have a baby also have a responsibility to maintain a healthy body weight and consume a balanced diet, because male obesity may affect fertility by altering testosterone and other hormone levels," Schantz said.